Salvia divinorum extracts are concentrated presentations made from dried leaves of Salvia divinorum Epling & Játiva, where the proportion of salvinorin A is increased through specialized extraction processes. In this subcategory, you will find six levels of concentration—from 5X to 80X—with technical information about concentration, format, and the extraction process for each reference. If you are looking for the unconcentrated presentation in plant material, check the section for leaves of Salvia divinorum. For a general overview of the species, you can visit the main category of Salvia divinorum.
The production of standardized extracts of Salvia divinorum is based on the differential solubility of salvinorin A compared to other components of the plant matrix. Salvinorin A is highly soluble in nonpolar solvents such as acetone and dichloromethane, while the major constituents of the leaf—cellulose, chlorophyll, tannins, flavonoids—exhibit very different solubility in these solvents, allowing for selective separation through liquid-solid extraction followed by solvent evaporation (Valdes, L.J. et al., 1984. Journal of Organic Chemistry, 49(24), 4716–4720).
The general process involves macerating the dried plant material in the selected solvent, filtering to remove the solid plant material, and controlled evaporation of the solvent to obtain a dry extract enriched in salvinorin A. The concentration factor—expressed as 5X, 10X, etc.—indicates the relationship between the amount of starting plant material and the final amount of extract produced: a 10X extract is obtained by processing approximately 10 grams of leaf per gram of resulting extract. The 80X extract requires additional purification methodology to achieve salvinorin A concentrations of 288 mg/g, significantly higher than would correspond to a strict linear progression of the scale (which would yield ~200 mg/g), reflecting additional stages of concentration and purification compared to lower-scale extracts (Roth, B.L. et al., 2002. PNAS, 99(18), 11934–11939).
The numerical scale of extracts indicates the relative concentration level of salvinorin A compared to the reference base leaf, taking an average concentration of 2.5 mg/g in standard dried leaf as a starting point. The scale serves to compare formats within the catalog—it does not indicate quality but concentration of salvinorin A per gram of extract. Higher concentration extracts (30X, 40X, 80X) are offered in a 0.5 g format instead of 1 g, as the amount of material per unit is proportionally lower based on concentration.
| Extract | Salvinorin A (approx.) | Format | Approx. Leaf Equivalent | Details |
|---|---|---|---|---|
| 5X | 12.5 mg/g | 1 g | ~5 g of leaf | View details |
| 10X | 25 mg/g | 1 g | ~10 g of leaf | View details |
| 20X | 50 mg/g | 1 g | ~20 g of leaf | View details |
| 30X | 75 mg/g | 0.5 g | ~15 g of leaf | View details |
| 40X | 100 mg/g | 0.5 g | ~20 g of leaf | View details |
| 80X | 288 mg/g | 0.5 g | ~144 g of leaf (differentiated methodology) | View details |
In addition to the individual extracts, Edabea offers a comparative extract pack with various concentrations within the same reference.
Salvinorin A (C₂₁H₂₃O₂) is the main secondary metabolite of Salvia divinorum and the reference compound in the standardization of extracts. It is a neoclerodane diterpenoid without nitrogen in its structure—unlike the vast majority of known natural psychoactive compounds, which are alkaloids—and acts as a potent and selective agonist of kappa opioid receptors (KOR) without activity on mu receptors (Roth, B.L. et al., 2002, op. cit.). It was first isolated and identified by Valdés, Díaz & Paul in 1984 (Valdes et al., 1984, op. cit.) and its pharmacological activity on kappa receptors was characterized by Roth and colleagues in 2002.
Salvinorin A has documented photosensitivity—susceptibility to photochemical degradation due to exposure to ultraviolet radiation and high-energy visible light—which determines the recommended storage conditions for both the extracts and the base plant material (Valdés, L.J. et al., 1994. Journal of Ethnopharmacology, 43(3), 171–179).
Extracts of Salvia divinorum should be stored in a hermetically sealed opaque container, in a cool, dry place, protected from direct light and sudden temperature changes. The photosensitivity of salvinorin A is especially relevant in high concentration extracts (30X, 40X, 80X), where the proportion of the compound per gram is maximized and partial degradation has a greater impact on the effective concentration of the material. Under proper storage conditions, the extracts can remain stable for extended periods.
Salvinorin A is included in the lists of controlled substances in several jurisdictions. The legal status of Salvia divinorum and its derivatives varies by country and may change over time. It is the buyer’s responsibility to verify the current regulations in their place of residence before purchasing any product in this category. All products are sold exclusively as botanical collection material and ethnobotanical research.
The extraction process is based on the differential solubility of salvinorin A compared to other components of the plant matrix. Salvinorin A is highly soluble in nonpolar solvents such as acetone or dichloromethane, while the major components of the leaf—cellulose, chlorophyll, tannins, flavonoids—have very different solubility in these mediums. The process involves macerating the dried plant material in the selected solvent, filtering out the residual solid, and controlled evaporation of the solvent to obtain a dry extract enriched in salvinorin A. The numerical factor of the scale indicates the approximate relationship between the starting plant material and the final extract: a 10X extract is obtained by processing ~10 grams of leaf per gram of resulting extract (Valdes et al., 1984, op. cit.).
The linear progression of the 5X–40X scale (12.5 / 25 / 50 / 75 / 100 mg/g) would suggest an approximate concentration of 200 mg/g for a hypothetical 80X. The 80X extract available at Edabea contains 288 mg/g of salvinorin A, a significantly higher concentration. This reflects that the extraction process for the 80X includes additional purification and concentration stages compared to lower scale extracts, reaching a level of salvinorin A concentration close to the technical feasible limit in this type of presentation. The designation 80X refers to the relative concentration factor compared to the base leaf, not to a strict arithmetic progression.
The presentation format of each extract is determined by the concentration of salvinorin A per unit. Higher concentration means less material is needed per reference to maintain a coherent proportion between concentration and product quantity. The extracts 5X, 10X, and 20X are offered in 1 g because the concentration per gram is lower; the extracts 30X, 40X, and 80X are provided in 0.5 g because the concentration per gram is significantly higher, making 0.5 g represent an amount of salvinorin A comparable to or greater than 1 g of the lower scale extracts.
The dried leaves retain the complete plant matrix—cellulose, chlorophyll, flavonoids, essential oils, and the complete set of secondary metabolites present in the species—with the natural concentration of salvinorin A documented between 0.89 and 3.87 mg/g depending on the material (Valdés et al., 1994, op. cit.). The extracts are the result of a selective extraction process that concentrates the salvinorin A by eliminating most of the plant matrix. The difference is not only quantitative but also qualitative: the leaf retains the full phytochemical complexity of the plant, while the extract is a concentrated fraction of one of its metabolites.
In a hermetically sealed opaque container, in a cool, dry place, protected from direct light and sudden temperature variations. Salvinorin A has documented photosensitivity—susceptibility to photochemical degradation due to exposure to ultraviolet radiation and visible light—which makes the use of opaque packaging or storage in the absence of light especially recommended (Valdés et al., 1994, op. cit.). This precaution is especially relevant in higher concentration extracts (30X, 40X, 80X), where the proportion of salvinorin A per gram is maximum and partial degradation has a greater impact on the effective concentration of the material.
Information prepared by the specialized team of Edabea Natura, with over 15 years of experience in selecting and marketing ethnobotanical materials. The phytochemical and ethnobotanical information is based on the cited bibliographic sources and on direct knowledge of the material of each batch. Last update: April 2026. For inquiries about availability or the current batch characteristics, contact contacto@edabea.com.
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