Harmala Freebase

Harmala Freebase â Purified extract of Peganum harmala | 1 g and 10 g

Harmala Freebase is the freebase form of harmala alkaloids, obtained through extraction and purification from Peganum harmala seeds (Syrian rue). It complements the Harmala HCl â two distinct chemical forms of the same alkaloids, with differing solubility properties. We offer it in two formats: 1 g and 10 g.

Composition and purity â supplier's specification

According to the specification provided by the supplier, Edabea's Harmala Freebase has the following alkaloid composition:

To obtain 1 g of Harmala Freebase, approximately 33 g of Peganum harmala seeds with an alkaloid content of 3% are required â data derived from the supplier's concentration specification and consistent with ranges documented in the phytochemical literature (Herraiz & Chaparro, 2006).

What is Harmala Freebase and how does it differ from HCl?

Harmala Freebase and Harmala HCl are two distinct chemical forms of the same harmala alkaloids. The Freebase is the non-salted form â less soluble in water, more soluble in organic solvents, with a lower vaporization temperature. The HCl is the salted form with hydrochloric acid â more soluble in water, crystalline salt form (Herraiz & Chaparro, 2006).

Ethnobotanical context â Peganum harmala

Peganum harmala (Syrian rue) is a plant distributed around the Mediterranean and Central Asia with documented presence in traditional medicine across multiple cultures since antiquity. Its seeds contain harmine, harmaline, and tetrahydroharmine â the same profile of beta-carboline alkaloids found in Banisteriopsis caapi â leading to its documentation as an alternative source of beta-carbolines in modern ethnobotanical literature (Ott, 1994; Herraiz & Chaparro, 2006).

The monoamine oxidase inhibitor (MAOI) activity of harmala alkaloids is well-documented in scientific literature since the work of McKenna et al. (1984) and has been the subject of multiple subsequent analytical and pharmacological studies (Herraiz & Chaparro, 2006).

Extraction process

Harmala Freebase is obtained through alkaloid extraction from Peganum harmala seeds followed by a purification process to isolate the alkaloids in freebase form. Approximately 33 g of seeds are required per gram of extract produced, consistent with documented ranges in literature for this species (Herraiz & Chaparro, 2006).

Storage

Harmala Freebase in freebase form is sensitive to moisture and direct light. To maintain stability:

• Store in a well-sealed container, preferably airtight.
• Keep in a cool, dry place protected from direct light.
• Avoid moisture and cross-contamination with other materials.

Frequently asked questions about Harmala Freebase

What are harmala alkaloids?

Harmala alkaloids â harmine, harmaline, and tetrahydroharmine â are beta-carboline compounds found in several plant species, including Peganum harmala and Banisteriopsis caapi. Their monoamine oxidase inhibitor (MAOI) activity has been documented since the works of McKenna et al. (1984) and has been the subject of multiple analytical and pharmacological studies (Herraiz & Chaparro, 2006).

What is the difference between Harmala Freebase and Harmala HCl?

They are two distinct chemical forms of the same alkaloids. The Freebase is the non-salted form â less soluble in water, more soluble in organic solvents. The HCl is the salted form â more soluble in water, crystalline presentation. The difference is chemical and determines their behavior in different media, influencing their relevance for various lines of phytochemical or analytical research (Herraiz & Chaparro, 2006).

What does it mean that the composition is "supplier's specification"?

The alkaloid composition data (47% harmine / 53% harmaline, purity 99%, absence of vasicine and vasicinone) are declared by the supplier of the material. Edabea does not have its own laboratory analysis for this reference. The data is consistent with documented ranges in phytochemical literature for purified extracts of Peganum harmala (Herraiz & Chaparro, 2006), but it is presented as a stated specification, not as independent analytical verification.

What is the legal status of Harmala Freebase?

The legal situation may vary depending on jurisdiction. It is the buyer's responsibility to verify applicable regulations in their place of residence. This product is marketed exclusively as a botanical collection material and for ethnobotanical research.

Which format is more suitable, 1 g or 10 g?

The 1 g format is suitable for collection, botanical archive, or initial study of the material. The 10 g format is aimed at researchers or collectors working with larger volumes or needing a more extensive batch reference for analytical or phytochemical comparisons.

About this content

This sheet was prepared by the specialized Edabea Natura team, with over 15 years of experience in the selection and marketing of ethnobotanical materials. The composition data comes from the supplier's specification; the phytochemical and ethnobotanical information is based on the cited bibliographic sources. Last update: April 2026. For inquiries regarding availability or characteristics of the current batch, contact contact@edabea.com.

References: Herraiz, T. & Chaparro, C. (2006). Human monoamine oxidase enzyme inhibition by coffee and β-carbolines norharman and harman. Life Sciences, 78(8), 795–802. — McKenna, D.J., Towers, G.H.N. & Abbott, F. (1984). Monoamine oxidase inhibitors in South American hallucinogenic plants. Journal of Ethnopharmacology, 10(2), 195–223. — Ott, J. (1994). Ayahuasca Analogues: Pangæan Entheogens. Kennewick: Natural Products.